People age dramatically twice, say scientists: Are you in that stage now? – The Times of India

Ageing is a natural process, but new research from Stanford University reveals that the body does not age in a steady, linear fashion. Instead, scientists have found that two specific ages—44 and 60—mark major turning points in health and molecular functions.
These findings, based on a study of 108 participants, show that the body undergoes significant biological changes at these ages, influencing metabolism, immune response, and even disease risk. Understanding these shifts can help in making lifestyle adjustments to maintain health and longevity.
Why ageing is not a continuous process
Many assume that aging happens gradually, but Stanford scientists discovered that certain biological markers change dramatically at specific points in life. By analysing blood proteins and molecular data over time, researchers observed that most changes occurred at 44 and 60 years of age, rather than progressing consistently.

These findings challenge the idea of a slow and steady aging process. Instead, they suggest that the body experiences “waves” of changes, where key functions suddenly shift. This means that health risks and bodily functions can take sudden turns at these specific ages.
What happens at age 44?
At around 44, noticeable metabolic and cardiovascular changes take place. Some of the key shifts include:
- Lipid and alcohol metabolism: The way the body processes fats and alcohol begins to change, which could impact weight management and liver health.
- Cardiovascular health: Signs of heart disease risk start appearing, even in those without symptoms.
- Hormonal changes: There is a noticeable shift in hormone levels, which can affect energy, mood, and metabolism.
- This period marks a crucial time to adopt healthier habits, as these changes may influence long-term well-being.

What happens at age 60?
The second major turning point occurs at around 60, when the body undergoes more significant functional declines. Some key changes include:
- Weakened immune system: The body’s ability to fight infections and recover from illnesses slows down.
- Carbohydrate metabolism shift: Blood sugar levels become harder to regulate, increasing the risk of diabetes.
- Kidney function decline: Blood urea nitrogen levels rise, indicating a gradual reduction in kidney efficiency.
- Cognitive and muscle changes: Signs of cognitive slowdown and muscle mass loss become more evident.
At this stage, prioritising a nutrient-rich diet, regular physical activity, and cognitive engagement becomes even more essential to maintain health.
What this means for long-term health
These findings suggest that interventions should be targeted at these two critical ages. Rather than assuming that health declines gradually, it is important to focus on making proactive changes before reaching these key life stages.
In the early 40s, focusing on heart health, metabolic balance, and stress management can help prevent future risks.
By the early 60s, boosting immunity, preserving muscle strength, and maintaining stable blood sugar levels became crucial.